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Moreover, the top-ranked peptide did not contain the amino acids in its sequence considered important for activating the GLP-1R and was thus reserved for future evaluations

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Likewise, in an AD model, SH-SY5Y cells were treated with A, semaglutide inhibited apoptosis by inhibiting the expression of Bax induced by A and increasing the expression of Bcl2 inhibited by A (200)

NR4A1 inhibits the ubiquitination degradation of P53 by regulating the downstream target gene MDM2, thereby affecting the oxidative respiration process of mitochondria, producing oxidized lipids, and inducing ferroptosis in cells